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Two key contributors: blood sugar reduction (even modest drops can cause tiredness during adaptation) and dehydration, since electrolyte imbalance prevents water from reaching cells even when fluid intake seems adequate

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PlexusDx Precision Peptide Genetic Test ($99 add-on) identifies genetic variants in GLP1R and MC4R pathways that influence individual semaglutide response rates and optimal dosing

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doi: 10.1016/J.DIABRES.2022.110202 117 MacPhersonKCooperKHarbourJMahalDMillerCNairnM